Maternal Implications in the Origin of Preeclampsia
Senior Principal Investigator: Tamara Garrido
Preeclampsia is a major obstetric complication affecting 8% of first-time pregnancies with grave consequences for both mother and child. Despite years of investigation, a complete understanding of pathogenesis remains elusive, which compounds the difficulties in identifying predictive biomarkers and developing targeted therapeutic strategies. The unsolved question is why shallow trophoblast invasion occurs during placentation; our group turned its attention to the maternal decidua.
We focus on deciphering the origin and causes of pregnancy complications, such as preeclampsia.
We have provided evidence of defective decidualization in the endometrium of women with preeclampsia, which is detected at delivery and lingers for years afterward.
Our primary challenge is elucidating the molecular mechanisms underlying this defect at single-cell resolution, which will help develop strategies for early detection and novel therapies focused on preventing and treating preeclampsia.
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