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Bio

Innovate, create, and educate.

Carlos Simón is Professor of Ob/Gyn at the University of Valencia (Spain), Senior Lecturer PT, BIDMC Harvard University, USA, and Adjunct Clinical Professor at Baylor College of Medicine, USA.

His main clinical and scientific interest is in understanding human embryonic implantation, a critical process to the survival of the species, considering the embryo, the maternal endometrium, and their cross-communication as crucial elements.

He discovered a transcriptomic signature of human endometrial receptivity using microarray technology (PMID: 20619403), which was confirmed by single-cell RNA sequencing (PMID: 32929266). Clinical translation of this research resulted in a patent for the creation of the endometrial receptivity analysis (ERA) to diagnose the personalized window of implantation in infertile patients. He provided evidence of a decidualization defect in the endometrium of women with severe preeclampsia, a pathology detectable at the time of delivery and persisting for years (PMC: 5635883), also discovering the footprint encoding this defect (PMC: 8553341). Next, he demonstrated that the human uterine cavity is not sterile, by reporting the existence of the endometrial microbiome (PMID: 27717732) and its functional implications in pregnancy (PMC: 8725275). He also discovered the existence and provided functional proof of concept for the existence of human endometrial stem cells. Today, these findings are being translated to the first advanced cellular therapy for Asherman’s Syndrome (PMID: 27005892)(EudraCT Number: 2016-003975-23). For the human embryo,he created a prediction model for aneuploidy in early embryo development revealed by single-cell analysis (PMID: 26151134), deciphered the clinical impact of embryo mosaicism (PMCID: PMC8715143), and discovered the origin and composition of human embryo cell-free DNA (PMID: 29471395) and its clinical impact (PMID: 32470458). His team derived, characterized, and registered ten human embryonic stem cell lines in the Spanish National Stem Cell Bank. (PMID: 20018958). His pioneering work in this field made possible the creation of the Valencia Node of the Spanish Stem Cell Bank in 2004. Finally, he addressed cross-communication between the maternal endometrium and the embryo (PMID: 29390102), discovering that maternal microRNAs might act as a transcriptomic modifier of the pre-implantation embryo (PMID: 26395145).

His commitment to excellence in research has been demonstrated by the publication of over 500 papers (PubMed) in peer-reviewed journals with an accumulated impact factor of 3,814.94. His papers have received over 44,000 citations, and he has a Google Scholar H-index of 120. He has edited 20 books in English, Spanish, and Portuguese and supervised 38 Ph.D. theses. Several scientific societies and institutions have awarded his research, including the Rey Jaime I Medical Research Award 2011, the ASRM Distinguished Research Award in 2016, and the Lilly Foundation Biomedical Research Award in 2021.

His commitment to excellence in clinical care has been demonstrated by his instrumental role as a clinician and scientific director in establishing IVI’s clinical practice and research program from 1994 to 2018 (www.ivirma.es). As an inventor and entrepreneur, his research has generated 15 patent applications that enabled the creation of Igenomix S.L. in 2011, in which he was a founder and the chief science officer (CSO), leading a scientific/medical team of 120 Ph.D. students worldwide until it was acquired by Vitrolife in 2021, a biotech company devoted to precision medicine in reproductive health through advanced reproductive genetic diagnoses with an international footprint on all continents.

Since 2022
  • Co-President and Founder of the Carlos Simon Foundation for Research in Women’s Health
2011-2022
  • Founder and Head of the Scientific Advisory Board of Igenomix.
2011-2012
  • President, BIOVAL (The Valencian Community BioRegion) Valencia, Spain.
2009-2011
  • Scientific Director, Príncipe Felipe Research Center (CIPF).
2005-2009
  • Department Coordinator of Regenerative Medicine, Príncipe Felipe Research Centre (CIPF).
2004-2011
  • Director, Valencia Stem Cell Bank; Príncipe Felipe Research Center, Valencia, Spain.
  • Valencia Node of the Spanish National Bank of Stem Cells, Institute of Health Carlos III, Ministry of Economy and Competitivity, Spanish Government.
1999-2005
  • Director and Chief Gynecologist in “Women’s Clinic” Buñol.
1994-2016
  • Scientific Director and Board Member of the IVI Foundation
1994-2016
  • Scientific Director of the Instituto Valenciano de Infertilidad (IVI)
Since 1994
  • IVI Head of Reproductive Endocrinology
1991
  • Adjunct Deputy Medical Doctor, University Clinical Hospital of Valencia.
1987-1991
  • Medical Resident, Dept of Obstetrics & Gynecology University Clinical Hospital of Valencia.
1987
  • Open Competitive Exams (MIR, #116).
1991-1994
  • Research Fellowship in Reproductive Endocrinology, Department of Obstetrics and Gynecology, Stanford University, USA.
1987-1991
  • Board Certified in Obstetrics and Gynecology, Clinical Hospital University of Valencia.
1986-1987
  • Doctor of Medicine and Surgery, University of Valencia.
1985-1986
  • Award of Excellence, University of Valencia.
1979-1985
  • Degree in Medicine and Surgery from the University of Valencia.